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QTL Variant Detail
QTL variant: SialsC3H/HeJ
Name: sialoadenitis susceptibility; C3H/HeJ
MGI ID: MGI:2384717
QTL: Sials  Location: unknown  Genetic Position: Chr4, Syntenic
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to sialoadenitis compared to MRL/MpJ.
Inheritance:    Dominant

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis using 139 markers at a density of 10 cM was performed on an MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr x (C3H/HeJ-Tnfrsf6lpr/Tnfrsf6lpr x MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr)F1 backcross population to map loci associated with 4 types of lesions involved in collagen disease: vasculitis, glomerulonephritis, arthritis, and sialoadenitis. Parental strain MRL/MpJ-Tnfrsf6lpr/Tnfrsf6lpr is susceptible to collagen disease whereas parental strain C3H/HeJ-Tnfrsf6lpr/Tnfrsf6lpr is resistant. A locus significantly linked to sialoadenitis susceptibility, Sials, in females mapped to mouse Chromosome 4 at approximately 48.5 cM (P<0.0001 at D4Mit255). The MRL/MpJ-derived allele confers recessively inherited susceptibility to sialoadenitis in female animals at this locus. Suggestive loci were also detected for susceptibility to vasculitis (P<0.0009 at D4Mit125), glomerulonephritis (P<0.0007 at D6Mit8), arthritis in males (P<0.0009 at D15Mit183), and sialoadenitis (P<0.0009 at D10Mit20 and D10Mit259).

Original:  J:66636 Nose M, et al., Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. Int J Cardiol. 2000 Aug 31;75 Suppl 1:S53-61; discussion S63
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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