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Etv1tm2Tmj
Targeted Allele Detail
Nomenclature
Symbol: Etv1tm2Tmj
Name: ets variant 1; targeted mutation 2, Thomas M Jessell
MGI ID: MGI:2384496
Synonyms: Er81nlslacZ, Er81NLZ
Gene: Etv1  Location: Chr12:38780082-38870483 bp, + strand  Genetic Position: Chr12, 17.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78232
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing nls-lacZ was inserted in frame into exon 2. While normal protein was undetected in homozygous mutant embryos at E13.5, approximately 5% of dorsal root ganglion neurons showed reactivity after E15. The authors believe the expression to be that of inactive protein lacking the activation domain. (J:78232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv1 Mutation:  30 strains or lines available
References
Original:  J:78232 Arber S, et al., ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory