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Targeted Allele Detail
Symbol: Sim2tm1Shmb
Name: single-minded family bHLH transcription factor 2; targeted mutation 1, M J Shamblott
MGI ID: MGI:2384488
Synonyms: Sim2 -/-, Sim2tm1Jdg
Gene: Sim2  Location: Chr16:94085260-94127032 bp, + strand  Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
Germline Transmission:  Earliest citation of germline transmission: J:78252
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence, encoding the initiator methionine and the first 47 amino acids of the basic helix-loop-helix domain, was deleted from exon 1 by the insertion of a neomycin cassette via homologous recombination. (J:78252)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim2 Mutation:  11 strains or lines available
Original:  J:78252 Shamblott MJ, et al., Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene. Dev Dyn. 2002 Aug;224(4):373-80
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory