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Ccl11tm1Mer
Targeted Allele Detail
Nomenclature
Symbol: Ccl11tm1Mer
Name: chemokine (C-C motif) ligand 11; targeted mutation 1, Marc E Rothenberg
MGI ID: MGI:2384435
Synonyms: Eot-, eotaxin-, eotaxin-1
Gene: Ccl11  Location: Chr11:82057832-82062955 bp, + strand  Genetic Position: Chr11, 49.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38945
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll of exon 2 and the majority of exon 3 were replaced by a neomycin selection cassette. In addition to containing the 3' UTR, the deleted region encoded most of the mature protein. Transcript was undetected in homozygous mutant mice via Northern blot analysis of skin and lung RNA (the latter of which was isolated from mice treated with and subsequently challenged with OVA).
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ccl11 Mutation:  10 strains or lines available
References
Original:  J:38945 Rothenberg ME, et al., Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 1997 Feb 17;185(4):785-90
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory