Pparg^tm1.1Gonz
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Gonz
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Frank J Gonzales
• MGI ID: MGI:2384321
• Synonyms: PPARgamma^fl
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75777
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Animals heterozygous for Pparg^tm1Gonz were crossed to an EIIa-cre transgenic line to delete the floxed PGK-neo cassette. The deletion event leaves behind single loxP sites flanking exon 2. Southern blot analysis confirmed the removal of PGK-neo in offspring. (J:75777)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pparg^tm1.1Gonz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 39 strains or lines available

References

• Original: J:75777 Akiyama TE, et al., Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr;22(8):2607-19
• All: 82 reference(s)