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Targeted Allele Detail
Symbol: Ppargtm1.1Gonz
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Frank J Gonzales
MGI ID: MGI:2384321
Synonyms: PPARgammafl
Gene: Pparg  Location: Chr6:115361221-115490401 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:75777
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAnimals heterozygous for Ppargtm1Gonz were crossed to an EIIa-cre transgenic line to delete the floxed PGK-neo cassette. The deletion event leaves behind single loxP sites flanking exon 2. Southern blot analysis confirmed the removal of PGK-neo in offspring. (J:75777)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  16 strains or lines available
Original:  J:75777 Akiyama TE, et al., Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr;22(8):2607-19
All:  57 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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