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Mlh3tm1Lpkn
Targeted Allele Detail
Nomenclature
Symbol: Mlh3tm1Lpkn
Name: mutL homolog 3; targeted mutation 1, Steven M Lipkin
MGI ID: MGI:2384218
Synonyms: Mlh3-
Gene: Mlh3  Location: Chr12:85234520-85270599 bp, - strand  Genetic Position: Chr12, 39.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78200
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 and downstream intronic sequence were replaced with a cassette containing lacZ and neo. Transcript was undetected by Nothern blot analysis of total testicular RNA. Immunofluorescence analysis of chromosomes during the meiosis I pachytene stage showed an absence of protein in homozygous mutant mice. (J:78200)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mlh3 Mutation:  20 strains or lines available
References
Original:  J:78200 Lipkin SM, et al., Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet. 2002 Aug;31(4):385-90
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory