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Targeted Allele Detail
Symbol: Cdkn2atm2.1Brn
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Anton Berns
MGI ID: MGI:2384164
Synonyms: Ink4a/Arf-, Ink4adelta2,3
Gene: Cdkn2a  Location: Chr4:89274473-89294619 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:71393
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated by breeding mice carrying Cdkn2atm2Brn with transgenic mice expressing cre. The expression of cre recombinase resulted in the excision of exons 2 and 3. The deletion of this region affects the expression of both isoforms, p16Ink4a and p19ARF. (J:71393)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  52 strains or lines available
Original:  J:71393 Krimpenfort P, et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 2001 Sep 6;413(6851):83-6
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory