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Targeted Allele Detail
Symbol: Ltbrtm1Kpf
Name: lymphotoxin B receptor; targeted mutation 1, Klaus Pfeffer
MGI ID: MGI:2384140
Synonyms: LTbetaR-, LTbetaRKO
Gene: Ltbr  Location: Chr6:125306571-125313885 bp, - strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:48837
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2 kb region of the gene from exon 1 to exon 5 was replaced with a neomycin resistance cassette via homologous recombination. The gene targeting event deletes bp 107-718 of the cDNA sequence. Northern blot analysis of liver from homozygous mutant animals using a full-length cDNA probe did not detect gene expression. Polyclonal antibodies directed against the extracellular domain of the protein did not react with mouse embryonic fibroblasts derived from homozygous mutant animals thus confirming the null allele. (J:48837)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltbr Mutation:  32 strains or lines available
Original:  J:48837 Futterer A, et al., The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 1998 Jul;9(1):59-70
All:  89 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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