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Ltbrtm1Kpf
Targeted Allele Detail
Nomenclature
Symbol: Ltbrtm1Kpf
Name: lymphotoxin B receptor; targeted mutation 1, Klaus Pfeffer
MGI ID: MGI:2384140
Synonyms: LTbetaR-, LTbetaRKO
Gene: Ltbr  Location: Chr6:125306571-125313885 bp, - strand  Genetic Position: Chr6, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48837
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2 kb region of the gene from exon 1 to exon 5 was replaced with a neomycin resistance cassette via homologous recombination. The gene targeting event deletes bp 107-718 of the cDNA sequence. Northern blot analysis of liver from homozygous mutant animals using a full-length cDNA probe did not detect gene expression. Polyclonal antibodies directed against the extracellular domain of the protein did not react with mouse embryonic fibroblasts derived from homozygous mutant animals thus confirming the null allele. (J:48837)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltbr Mutation:  4 strains or lines available
References
Original:  J:48837 Futterer A, et al., The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 1998 Jul;9(1):59-70
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory