Ptpn1^tm1Bbk
Targeted Allele Detail

Summary

• Symbol: Ptpn1^tm1Bbk
• Name: protein tyrosine phosphatase, non-receptor type 1; targeted mutation 1, Barabra B Kahn
• MGI ID: MGI:2384135
• Synonyms: Ex1^-, PTP-1B^-, PTP1B^-
• Gene: Ptpn1 Location: Chr2:167773977-167821305 bp, + strand Genetic Position: Chr2, 87.99 cM, cytoband H3
• Alliance: Ptpn1^tm1Bbk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63236
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and surrounding sequence were replaced with a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was verified by Northern and Western blot analyses of a variety of tissues. (J:63236)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ptpn1 Mutation: 36 strains or lines available

References

• Original: J:63236 Klaman LD, et al., Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug;20(15):5479-89
• All: 45 reference(s)