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Ptpn1tm1Bbk
Targeted Allele Detail
Nomenclature
Symbol: Ptpn1tm1Bbk
Name: protein tyrosine phosphatase, non-receptor type 1; targeted mutation 1, Barabra B Kahn
MGI ID: MGI:2384135
Synonyms: Ex1-, PTP-1B-, PTP1B-
Gene: Ptpn1  Location: Chr2:167932057-167979385 bp, + strand  Genetic Position: Chr2, 87.99 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63236
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and surrounding sequence were replaced with a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was verified by Northern and Western blot analyses of a variety of tissues. (J:63236)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptpn1 Mutation:  29 strains or lines available
References
Original:  J:63236 Klaman LD, et al., Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug;20(15):5479-89
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory