Fshr^tm1Mha
Targeted Allele Detail

Summary

• Symbol: Fshr^tm1Mha
• Name: follicle stimulating hormone receptor; targeted mutation 1, Margaret H Abel
• MGI ID: MGI:2384130
• Synonyms: FSHRKO
• Gene: Fshr Location: Chr17:89292380-89508103 bp, - strand Genetic Position: Chr17, 58.76 cM, cytoband E5
• Alliance: Fshr^tm1Mha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61909
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which contains the translational start site, was deleted along with downstream intronic sequence by the insertion of a neomycin selection cassette. (J:61909)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fshr^tm1Mha

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fshr Mutation: 49 strains or lines available

References

• Original: J:61909 Abel MH, et al., The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology. 2000 May;141(5):1795-803
• All: 9 reference(s)