About   Help   FAQ
Targeted Allele Detail
Symbol: Plp1tm1Wst
Name: proteolipid protein (myelin) 1; targeted mutation 1, Wilhelm Stoffel
MGI ID: MGI:2384125
Synonyms: plp-, plp/dm20/neo
Gene: Plp1  Location: ChrX:136822671-136839733 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:21976
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into intron 3 via homologous recombination to disrupt splicing of the gene product. Northern blot analysis confirmed the absence of normal transcripts in the brain of homozygous mutant animals. Western blot analysis and silver stained SDS-PAGE gels of myelin samples from homozygous mutants did not detect protein product of either isoform, PLP or DM20. (J:21976)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:  16 strains or lines available
Original:  J:21976 Boison D, et al., Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11709-13
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory