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Adipoqtm1Tka
Targeted Allele Detail
Nomenclature
Symbol: Adipoqtm1Tka
Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2384094
Synonyms: adipo-
Gene: Adipoq  Location: Chr16:23146536-23158028 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77876
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in serum of homozygous mutants. (J:77876)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:  25 strains or lines available
References
Original:  J:77876 Kubota N, et al., Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002 Jul 19;277(29):25863-6
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory