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Targeted Allele Detail
Symbol: Adipoqtm1Tka
Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2384094
Synonyms: adipo-
Gene: Adipoq  Location: Chr16:23146536-23157968 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
Germline Transmission:  Earliest citation of germline transmission: J:77876
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in serum of homozygous mutants. (J:77876)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:  29 strains or lines available
Original:  J:77876 Kubota N, et al., Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002 Jul 19;277(29):25863-6
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory