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Syktm1Tyb
Targeted Allele Detail
Nomenclature
Symbol: Syktm1Tyb
Name: spleen tyrosine kinase; targeted mutation 1, Victor L J Tybulewicz
MGI ID: MGI:2384078
Synonyms: syk-
Gene: Syk  Location: Chr13:52583173-52648792 bp, + strand  Genetic Position: Chr13, 27.41 cM, cytoband B-C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29796
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a neomycin selection cassette disrupted the exon encoding the subdomain I of the kinase domain. The absence of protein in mice homozygous for the allele was verified by Western blot analysis. (J:29796, J:97055)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syk Mutation:  15 strains or lines available
References
Original:  J:29796 Turner M, et al., Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995 Nov 16;378(6554):298-302
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory