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Targeted Allele Detail
Symbol: Tfpitm1Gjb
Name: tissue factor pathway inhibitor; targeted mutation 1, George J Broze
MGI ID: MGI:2384068
Synonyms: TFPI-, TFPI(desK1), TFPI(K1)-
Gene: Tfpi  Location: Chr2:84432855-84476775 bp, - strand  Genetic Position: Chr2, 49.41 cM
Germline Transmission:  Earliest citation of germline transmission: J:41945
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA region containing a portion of exon 4, encoding the first Kunitz domain, and intron 4 was replaced with a neomycin selection cassette. A truncated peptide, putatively translated from an aberrantly spliced transcript lacking sequence encoding the Kunitz domain, was detected in heterozygotes by Western blot analysis. Densitometric analysis of the blot showed the level of mutant protein in heterozygotes to be approximately 41% of the level of normal protein in wild-type mice. Functional activity was found to be reduced by approximately 46% in heterozygous mutant mice and 100% in homozygotes. (J:41945, J:51137)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfpi Mutation:  40 strains or lines available
Original:  J:41945 Huang ZF, et al., Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997 Aug 1;90(3):944-51
All:  10 reference(s)

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MGI 6.10
The Jackson Laboratory