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Targeted Allele Detail
Symbol: Fgrtm2Hev
Name: FGR proto-oncogene, Src family tyrosine kinase; targeted mutation 2, Harold E Varmus
MGI ID: MGI:2384041
Synonyms: fgr-delta4
Gene: Fgr  Location: Chr4:132974095-133001910 bp, + strand  Genetic Position: Chr4, 66.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:16994
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette replaced exon 4 and precluded the complete translation of proteins initiated from a potential start codon at position 59 in the 3' terminal of exon 2. Normal protein was undetected by Western blot analysis of homozygous mutant mice, however, the lack of truncated carboxy terminal peptides was not directly verified. (J:16994)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgr Mutation:  120 strains or lines available
Original:  J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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