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Fggtm1Fjc
Targeted Allele Detail
Nomenclature
Symbol: Fggtm1Fjc
Name: fibrinogen gamma chain; targeted mutation 1, Francis J Castellino
MGI ID: MGI:2384029
Synonyms: FG-, Fib-
Gene: Fgg  Location: Chr3:83007724-83015049 bp, + strand  Genetic Position: Chr3, 36.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64396
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region of the endogenous locus was replaced with a neomycin selection cassette. Western blot analysis of blood plasma showed the absence of the gamma polypeptide, preventing the formation of the fibrinogen heterodimer in homozygous mutant mice. (J:64396)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgg Mutation:  17 strains or lines available
References
Original:  J:64396 Ploplis VA, et al., A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol. 2000 Sep;157(3):703-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory