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F11tm1Gjb
Targeted Allele Detail
Nomenclature
Symbol: F11tm1Gjb
Name: coagulation factor XI; targeted mutation 1, George J Broze
MGI ID: MGI:2384015
Synonyms: FXI-
Gene: F11  Location: Chr8:45241174-45262031 bp, - strand  Genetic Position: Chr8, 25.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40270
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 5, encoding a portion of the second apple domain, was disrupted by the insertion of a neomycin selection cassette. Sequence analysis showed that a frameshift mutation would be generated if exon 4 were to splice to exon 6 due to the excision of the disrupted exon 5. Transcript was undetected in homozygous mutant mice via Northern blot and RT-PCR analyses of total hepatic RNA. (J:40270)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any F11 Mutation:  1 strain or line available
References
Original:  J:40270 Gailani D, et al., A murine model of factor XI deficiency. Blood Coagul Fibrinolysis. 1997 Mar;8(2):134-44
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory