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Fgf2tm1Bas
Targeted Allele Detail
Nomenclature
Symbol: Fgf2tm1Bas
Name: fibroblast growth factor 2; targeted mutation 1, Claudio Basilico
MGI ID: MGI:2384001
Synonyms: FGF2-
Gene: Fgf2  Location: Chr3:37348346-37410108 bp, + strand  Genetic Position: Chr3, 18.41 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47664
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassetted deleted a region of exon 1 encoding 59 amino acids and including the splicing donor site. Transcript was undetected in homozygous mutant mice via RT-PCR analysis. Western blot analysis of protein extracts obtained from various organs confirmed the absence of the 3 known isoforms produced from the endogenous locus. (J:47664)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf2 Mutation:  10 strains or lines available
References
Original:  J:47664 Ortega S, et al., Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5672-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory