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Ube2btm1Jhjh
Targeted Allele Detail
Nomenclature
Symbol: Ube2btm1Jhjh
Name: ubiquitin-conjugating enzyme E2B; targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:2183933
Synonyms: HR6b-, mHR6B-
Gene: Ube2b  Location: Chr11:51985497-52000762 bp, - strand  Genetic Position: Chr11, 31.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35244
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by the insertion of a neomycin selection cassette immediately following the start codon. Northern blot analysis showed an absence of transcript in homozygous mutant mice. The absence of protein produced from Ube2b was determined via Western blot analysis of testicular extracts. Further analysis showed that the level of protein produced from the homologous Ube2a locus was unaffected by the targeting event. (J:35244)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ube2b Mutation:  13 strains or lines available
References
Original:  J:35244 Roest HP, et al., Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification. Cell. 1996 Sep 6;86(5):799-810
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory