Npy4r^tm1Hhz
Targeted Allele Detail

Summary

• Symbol: Npy4r^tm1Hhz
• Name: neuropeptide Y receptor Y4; targeted mutation 1, Herbert Herzog
• MGI ID: MGI:2183928
• Synonyms: FY4, Y4^lox
• Gene: Npy4r Location: Chr14:33867603-33874376 bp, - strand Genetic Position: Chr14, 20.8 cM
• Alliance: Npy4r^tm1Hhz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76479
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted downstream of the Ppyr1 gene and a third loxP site was introduced into intron 1 via homologous recombination. The mutant allele was confirmed by Southern blot analysis of targeted ES cells using a probe to the Ppyr1 coding region. (J:76479)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npy4r Mutation: 16 strains or lines available

References

• Original: J:76479 Sainsbury A, et al., Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev. 2002 May 1;16(9):1077-88
• All: 6 reference(s)