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Mapk3tm1Gpg
Targeted Allele Detail
Nomenclature
Symbol: Mapk3tm1Gpg
Name: mitogen-activated protein kinase 3; targeted mutation 1, Gilles Pages
MGI ID: MGI:2183906
Synonyms: ERK1-, MAPK-, p44 MAPK-
Gene: Mapk3  Location: Chr7:126759626-126765816 bp, + strand  Genetic Position: Chr7, 69.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58468
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted exonic sequence encoding the essential kinase subdomains 5 and 6. Immunoblot analysis of protein extracts from MEFs and various tissues showed an absence of protein in homozygous mutant mice. (J:58468)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk3 Mutation:  14 strains or lines available
References
Original:  J:58468 Pages G, et al., Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 1999 Nov 12;286(5443):1374-7
All:  56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory