About   Help   FAQ
Mapk3tm1Gpg
Targeted Allele Detail
Nomenclature
Symbol: Mapk3tm1Gpg
Name: mitogen-activated protein kinase 3; targeted mutation 1, Gilles Pages
MGI ID: MGI:2183906
Synonyms: ERK1-, MAPK-, p44 MAPK-
Gene: Mapk3  Location: Chr7:126759601-126765819 bp, + strand  Genetic Position: Chr7, 69.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58468
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted exonic sequence encoding the essential kinase subdomains 5 and 6. Immunoblot analysis of protein extracts from MEFs and various tissues showed an absence of protein in homozygous mutant mice. (J:58468)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk3 Mutation:  13 strains or lines available
References
Original:  J:58468 Pages G, et al., Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 1999 Nov 12;286(5443):1374-7
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory