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Targeted Allele Detail
Symbol: Hspa1atm1Msk
Name: heat shock protein 1A; targeted mutation 1, Demetrius Moskophidis
MGI ID: MGI:2183895
Synonyms: hsp70.3-
Gene: Hspa1a  Location: Chr17:34969359-34972156 bp, - strand  Genetic Position: Chr17, 18.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:72943
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of the coding region of the gene (codons 1-633) was replaced with an in frame lacZ floxed TK-neo cassette via homologous recombination. Southern blot and PCR genotype analysis confirmed the targeted allele in homozygous mutant animals. (J:72943)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspa1a Mutation:  17 strains or lines available
Original:  J:72943 Huang L, et al., Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice with Targeted Gene Disruption of the hsp70.1 or hsp70.3 Gene. Mol Cell Biol. 2001 Dec;21(24):8575-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory