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Myh4tm1Lnwd
Targeted Allele Detail
Summary
Symbol: Myh4tm1Lnwd
Name: myosin, heavy polypeptide 4, skeletal muscle; targeted mutation 1, Leslie A Leinwand
MGI ID: MGI:2183830
Synonyms: IIb-
Gene: Myh4  Location: Chr11:67128855-67151272 bp, + strand  Genetic Position: Chr11, 40.59 cM
Alliance: Myh4tm1Lnwd page
Muscle abnormalities, such as increased muscle fiber size and interstitial fibrosis, in Myh1tm1Lnwd/Myh1tm1Lnwd and Myh4tm1Lnwd/Myh4tm1Lnwd mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44448
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 3, which is the first coding exon, was disrupted by the insertion of a neomycin selection cassette. Low levels of transcript were detected in homozygous mutant mice by RNAse protection assays, however, Western blot analysis showed an absence of encoded protein. (J:44448)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh4 Mutation:  94 strains or lines available
References
Original:  J:44448 Acakpo-Satchivi LJ, et al., Growth and muscle defects in mice lacking adult myosin heavy chain genes. J Cell Biol. 1997 Dec 1;139(5):1219-29
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory