Myh4tm1Lnwd
Targeted Allele Detail
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Symbol: |
Myh4tm1Lnwd |
Name: |
myosin, heavy polypeptide 4, skeletal muscle; targeted mutation 1, Leslie A Leinwand |
MGI ID: |
MGI:2183830 |
Synonyms: |
IIb- |
Gene: |
Myh4 Location: Chr11:67128855-67151272 bp, + strand Genetic Position: Chr11, 40.59 cM
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Alliance: |
Myh4tm1Lnwd page
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Muscle abnormalities, such as increased muscle fiber size and interstitial fibrosis, in Myh1tm1Lnwd/Myh1tm1Lnwd and Myh4tm1Lnwd/Myh4tm1Lnwd mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:44448
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exon 3, which is the first coding exon, was disrupted by the insertion of a neomycin selection cassette. Low levels of transcript were detected in homozygous mutant mice by RNAse protection assays, however, Western blot analysis showed an absence of encoded protein.
(J:44448)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Myh4 Mutation: |
94 strains or lines available
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Original: |
J:44448 Acakpo-Satchivi LJ, et al., Growth and muscle defects in mice lacking adult myosin heavy chain genes. J Cell Biol. 1997 Dec 1;139(5):1219-29 |
All: |
4 reference(s) |
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