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Acta1tm1Jll
Targeted Allele Detail
Nomenclature
Symbol: Acta1tm1Jll
Name: actin, alpha 1, skeletal muscle; targeted mutation 1, James L Lessard
MGI ID: MGI:2183817
Gene: Acta1  Location: Chr8:123891769-123894751 bp, - strand  Genetic Position: Chr8, 72.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78070
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of an hprt minigene. Northern blot analysis of total RNA obtained from limbs showed an absence of transcript in homozygous mutant mice. (J:78070)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acta1 Mutation:  2 strains or lines available
References
Original:  J:78070 Crawford K, et al., Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period. Mol Cell Biol. 2002 Aug;22(16):5887-96
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory