Ncoa2tm1.2Ipc
Targeted Allele Detail
|
Symbol: |
Ncoa2tm1.2Ipc |
Name: |
nuclear receptor coactivator 2; targeted mutation 1.2, I Pierre Chambon |
MGI ID: |
MGI:2183803 |
Synonyms: |
SRC-2-, TIF-2-, TIF2-, TIF2L- |
Gene: |
Ncoa2 Location: Chr1:13209329-13444307 bp, - strand Genetic Position: Chr1, 4.12 cM, cytoband A3-A5
|
Alliance: |
Ncoa2tm1.2Ipc page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:78075
|
Parent Cell Line: |
H1 (ES Cell)
|
Strain of Origin: |
129S2/SvPas
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutation: |
|
Intragenic deletion
|
|
|
Mutation details: This allele was generated by breeding mice carrying Ncoa2tm1Ipc with transgenic mice expressing cre recombinase via the CMV promoter. The expression of cre resulted in the excision of the floxed region containing the neo transgene and the exon encoding the nuclear receptor interaction domain. Sequence analysis showed that a frameshift mutation begining at codon 375 introduced a stop codon at position 490. Immunohistochemical staining of homozygous mutant testes showed an absence of reactivity.
(J:78075)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ncoa2 Mutation: |
76 strains or lines available
|
|
Original: |
J:78075 Gehin M, et al., The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002 Aug;22(16):5923-37 |
All: |
24 reference(s) |
|