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Targeted Allele Detail
Symbol: Ncoa2tm1.2Ipc
Name: nuclear receptor coactivator 2; targeted mutation 1.2, I Pierre Chambon
MGI ID: MGI:2183803
Synonyms: SRC-2-, TIF-2-, TIF2-, TIF2L-
Gene: Ncoa2  Location: Chr1:13139105-13374083 bp, - strand  Genetic Position: Chr1, 4.12 cM, cytoband A3-A5
Germline Transmission:  Earliest citation of germline transmission: J:78075
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated by breeding mice carrying Ncoa2tm1Ipc with transgenic mice expressing cre recombinase via the CMV promoter. The expression of cre resulted in the excision of the floxed region containing the neo transgene and the exon encoding the nuclear receptor interaction domain. Sequence analysis showed that a frameshift mutation begining at codon 375 introduced a stop codon at position 490. Immunohistochemical staining of homozygous mutant testes showed an absence of reactivity. (J:78075)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa2 Mutation:  52 strains or lines available
Original:  J:78075 Gehin M, et al., The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002 Aug;22(16):5923-37
All:  24 reference(s)

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MGI 6.11
The Jackson Laboratory