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Transgene Detail
Symbol: Tg(PMP22)C22Clh
Name: transgene insertion C22, Clare Huxley
MGI ID: MGI:2183770
Synonyms: C22
Transgene: Tg(PMP22)C22Clh  Location: unknown  Genetic Position: Chr8, Syntenic
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PMP22)C22Clh expresses 1 gene
Mutation detailsA YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Founder C22 carries 8 copies of the human transgene on chromosome 8 with an expression pattern similar to that of the endogenous mouse gene. The expression level of each human transgene is approximately 0.4X that of one mouse gene. (J:78221)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:78221 Huxley C, et al., Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA. Hum Mol Genet. 1996 May;5(5):563-9
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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