About   Help   FAQ
Map2k7tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Map2k7tm1Flv
Name: mitogen-activated protein kinase kinase 7; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2183768
Synonyms: Mkk7-
Gene: Map2k7  Location: Chr8:4238740-4247897 bp, + strand  Genetic Position: Chr8, 1.99 cM, cytoband A1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61895
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details3 exons were replaced by a floxed puromycin selection cassette, which was subsequently excised via transient transfection of ES cells with a cre expression vector. Western blot analysis of homozygous mutant ES cells showed an absence of encoded protein. (J:61895)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k7 Mutation:  6 strains or lines available
References
Original:  J:61895 Dong C, et al., JNK is required for effector T-cell function but not for T-cell activation. Nature. 2000 May 4;405(6782):91-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/18/2017
MGI 6.08
The Jackson Laboratory