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Map2k7tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Map2k7tm1Flv
Name: mitogen-activated protein kinase kinase 7; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2183768
Synonyms: Mkk7-
Gene: Map2k7  Location: Chr8:4238740-4247897 bp, + strand  Genetic Position: Chr8, 1.99 cM, cytoband A1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61895
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details3 exons were replaced by a floxed puromycin selection cassette, which was subsequently excised via transient transfection of ES cells with a cre expression vector. Western blot analysis of homozygous mutant ES cells showed an absence of encoded protein. (J:61895)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k7 Mutation:  6 strains or lines available
References
Original:  J:61895 Dong C, et al., JNK is required for effector T-cell function but not for T-cell activation. Nature. 2000 May 4;405(6782):91-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory