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Targeted Allele Detail
Symbol: Sftpa1tm1Kor
Name: surfactant associated protein A1; targeted mutation 1, Thomas R Korfhagen
MGI ID: MGI:2183737
Synonyms: SP-A(-)
Gene: Sftpa1  Location: Chr14:40853745-40858330 bp, + strand  Genetic Position: Chr14, 22.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:35250
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exons 3 and 4 (base pairs 795 through 1049) were deleted by the insertion of a PGK-neo cassette. Northern blot analysis of RNA obtained from lung tissue showed an absence of transcript in homozygous mutant mice. The lack of encoded protein was confirmed by Western blot analysis of lung homogenates and immunohistochemical staining of alveolar type II cells. (J:35250)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sftpa1 Mutation:  13 strains or lines available
Original:  J:35250 Korfhagen TR, et al., Altered surfactant function and structure in SP-A gene targeted mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9594-9
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory