Icmttm1Hzo
Targeted Allele Detail
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Symbol: |
Icmttm1Hzo |
Name: |
isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Huda Y Zoghbi |
MGI ID: |
MGI:2183607 |
Synonyms: |
pccmt- |
Gene: |
Icmt Location: Chr4:152381684-152391578 bp, + strand Genetic Position: Chr4, 83.02 cM
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Alliance: |
Icmttm1Hzo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:77742
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: A floxed region containing exons 2 through 4 was excised via the in vitro expression of cre recombinase. The deleted sequence encoded amino acids 65 through 224. Northern blot analysis of heterozygous mice showed an approximately 50% reduction in transcript levels, whereas transcript was undetected in homozygous mutant embryos by RT-PCR analysis.
(J:77742)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Icmt Mutation: |
11 strains or lines available
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Original: |
J:77742 Lin X, et al., Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 2002 Jul;123(1):345-51 |
All: |
1 reference(s) |
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