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Targeted Allele Detail
Symbol: Icmttm1Hzo
Name: isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Huda Zoghbi
MGI ID: MGI:2183607
Synonyms: pccmt-
Gene: Icmt  Location: Chr4:152297227-152307121 bp, + strand  Genetic Position: Chr4, 83.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:77742
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed region containing exons 2 through 4 was excised via the in vitro expression of cre recombinase. The deleted sequence encoded amino acids 65 through 224. Northern blot analysis of heterozygous mice showed an approximately 50% reduction in transcript levels, whereas transcript was undetected in homozygous mutant embryos by RT-PCR analysis. (J:77742)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icmt Mutation:  7 strains or lines available
Original:  J:77742 Lin X, et al., Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 2002 Jul;123(1):345-51
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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