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Targeted Allele Detail
Symbol: Mapk7tm1Kda
Name: mitogen-activated protein kinase 7; targeted mutation 1, Keisuke Kuida
MGI ID: MGI:2183604
Synonyms: erk5-
Gene: Mapk7  Location: Chr11:61488812-61494406 bp, - strand  Genetic Position: Chr11, 37.96 cM
Mapk7tm1Kda/Mapk7tm1Kda embryos display multiple defects in cardiac development

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77725
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exons 2 and 3 were replaced with a neomycin selection cassette. Western blot analysis showed an absence of encoded protien in embryonic fibroblasts derived from homozygous mutant mice. (J:77725)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk7 Mutation:  20 strains or lines available
Original:  J:77725 Regan CP, et al., Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9248-53
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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