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Mc3rtm1Lvp
Targeted Allele Detail
Nomenclature
Symbol: Mc3rtm1Lvp
Name: melanocortin 3 receptor; targeted mutation 1, Lex H T Van der Ploeg
MGI ID: MGI:2183582
Synonyms: MC3-, Mc3r-
Gene: Mc3r  Location: Chr2:172248492-172251114 bp, + strand  Genetic Position: Chr2, 94.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64365
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region was replaced with a neomycin selection cassette. Transcript was identified to be absent in the brains of homozygous mutant mice via in situ hybridization. (J:64365)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mc3r Mutation:  23 strains or lines available
References
Original:  J:64365 Chen AS, et al., Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000 Sep;26(1):97-102
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory