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Mc3rtm1Cone
Targeted Allele Detail
Nomenclature
Symbol: Mc3rtm1Cone
Name: melanocortin 3 receptor; targeted mutation 1, Roger D Cone
MGI ID: MGI:2183579
Synonyms: mc3r-
Gene: Mc3r  Location: Chr2:172248492-172251114 bp, + strand  Genetic Position: Chr2, 94.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78132
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details0.7kb of sequence was replaced with a neomycin selection cassette at the initiation codon. Homozygous mutant mice were shown to lack transcript via RT-PCR analysis of total hypthalamic RNA. (J:78132)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc3r Mutation:  16 strains or lines available
References
Original:  J:78132 Butler AA, et al., A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology. 2000 Sep;141(9):3518-21
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory