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Nhlh1tm1Irk
Targeted Allele Detail
Nomenclature
Symbol: Nhlh1tm1Irk
Name: nescient helix loop helix 1; targeted mutation 1, Ilan R Kirsch
MGI ID: MGI:2183573
Synonyms: Nhlh1-
Gene: Nhlh1  Location: Chr1:171879859-171885140 bp, - strand  Genetic Position: Chr1, 79.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78031
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding sequence, which is entirely contained in exons 1 and 2, was replaced with a neomycin selection cassette. Transcript was determined to be absent in homozygous mutant mice via Northern blot analysis. (J:78031)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nhlh1 Mutation:  14 strains or lines available
References
Original:  J:78031 Cogliati T, et al., Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice. Mol Cell Biol. 2002 Jul;22(14):4977-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory