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Targeted Allele Detail
Symbol: Agttm1Ii
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); targeted mutation 1, Iekuni Ichikawa
MGI ID: MGI:2183545
Synonyms: Agt-, Angt-KO
Gene: Agt  Location: Chr8:124556587-124569706 bp, - strand  Genetic Position: Chr8, 72.81 cM
Abnormal kidney morphology in 3 week old Agttm1Ii/Agttm1Ii mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:30061
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.5 kb region of the gene containing exon 2 was replaced with a PGK-neo cassette via homologous recombination. Exon 2 encodes the translation start site and the entire octapeptide region of the protein. Absence of gene expression was confirmed in homozygous mutant animals by Northern blot analysis of liver tissue. Furthermore, no plasma angiotensinogen could be detected in homozygous mutant animals. (J:30061)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agt Mutation:  8 strains or lines available
Original:  J:30061 Niimura F, et al., Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest. 1995 Dec;96(6):2947-54
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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