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Agtr1atm1Tma
Targeted Allele Detail
Nomenclature
Symbol: Agtr1atm1Tma
Name: angiotensin II receptor, type 1a; targeted mutation 1, Taiji Matsusaka
MGI ID: MGI:2183541
Synonyms: Agtr1a-, Agtr1alacZ
Gene: Agtr1a  Location: Chr13:30336441-30382867 bp, + strand  Genetic Position: Chr13, 13.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36090
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details190 bp of the gene coding region was replaced with a lacZ-PGK-hygro cassette via homologous recombination. The lacZ-PGK-hygro cassette was inserted in frame after the third transmembrane domain. Northern blot analysis of kidney tissue confirmed the absence of gene expression in homozygous mutant animals. The expression pattern of beta-galactosidase in mutant animals is similar to that of the endogenous protein. (J:36090)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agtr1a Mutation:  15 strains or lines available
References
Original:  J:36090 Matsusaka T, et al., Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest. 1996 Oct 15;98(8):1867-77
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory