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Targeted Allele Detail
Symbol: Ncoa1tm1Bwo
Name: nuclear receptor coactivator 1; targeted mutation 1, Bert W O'Malley
MGI ID: MGI:2183532
Synonyms: SRC-1-, SRC-1 KO
Gene: Ncoa1  Location: Chr12:4247362-4477182 bp, - strand  Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:46528
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe insertion of a vector containing a GLVP cassette and a neomycin resistance gene changed an internal ATG codon (methionine 381) to a stop codon and deleted 9kb of sequence. The deleted region encoded all of the functional domains except for the bHLH-PAS domain. Western blotting of renal and hepatic protein extracts showed the absence of full-length protein in homozygous mutant mice. (J:46528)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa1 Mutation:  152 strains or lines available
Original:  J:46528 Xu J, et al., Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998 Mar 20;279(5358):1922-5
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory