Ncoa1tm1Bwo
Targeted Allele Detail
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Symbol: |
Ncoa1tm1Bwo |
Name: |
nuclear receptor coactivator 1; targeted mutation 1, Bert W O'Malley |
MGI ID: |
MGI:2183532 |
Synonyms: |
SRC-1-, SRC-1 KO |
Gene: |
Ncoa1 Location: Chr12:4297362-4527182 bp, - strand Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
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Alliance: |
Ncoa1tm1Bwo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:46528
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The insertion of a vector containing a GLVP cassette and a neomycin resistance gene changed an internal ATG codon (methionine 381) to a stop codon and deleted 9kb of sequence. The deleted region encoded all of the functional domains except for the bHLH-PAS domain. Western blotting of renal and hepatic protein extracts showed the absence of full-length protein in homozygous mutant mice.
(J:46528)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ncoa1 Mutation: |
169 strains or lines available
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Original: |
J:46528 Xu J, et al., Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998 Mar 20;279(5358):1922-5 |
All: |
45 reference(s) |
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