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Targeted Allele Detail
Symbol: Fgfr2tm3.1Lni
Name: fibroblast growth factor receptor 2; targeted mutation 3.1, Peter Lonai
MGI ID: MGI:2183529
Synonyms: Fgfr2IIIc-
Gene: Fgfr2  Location: Chr7:130162451-130266944 bp, - strand  Genetic Position: Chr7, 73.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:77698
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeted mutation is derived from Fgfr2tm3Lni by crossing to a cre-expressing line to remove the floxed neomycin cassette from intron 9. The engineered stop codon in exon 9 was left intact. The FgfrIIIc-specific absence of gene expression in homozygous mutant animals was verified by in situ hybridization. (J:77698)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  24 strains or lines available
Original:  J:77698 Eswarakumar VP, et al., The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002 Aug 15;129(16):3783-93
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory