Pkd1^tm1Maa
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1Maa
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, M Armin Arnout
• MGI ID: MGI:2183523
• Synonyms: Pkd1^L
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1Maa page

Histological analysis of tissues from Pkd1^tm1Maa/Pkd1^tm1Maa embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68331
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 43, exon 44, and part of exon 45 were replaced with a neomycin resistance cassette in the reverse orientation via homologous recombination. The gene targeting event introduces a stop codon into exon 43. The mutant allele was confirmed in heterozygous and homozygous animals by Northern blot analysis. (J:68331)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 153 strains or lines available

References

• Original: J:68331 Kim K, et al., Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1731-6
• All: 2 reference(s)