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Targeted Allele Detail
Symbol: Hnf4atm1.1Gonz
Name: hepatic nuclear factor 4, alpha; targeted mutation 1.1, Frank J Gonzalez
MGI ID: MGI:2183520
Synonyms: Hnf4aloxP, HNF4-alphafl, HNF4-alphaflox, HNF4alphaflox, HNF4alpha-flox, hnf4fl
Gene: Hnf4a  Location: Chr2:163506808-163572910 bp, + strand  Genetic Position: Chr2, 84.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:67396
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThis allele was generated by breeding mice carrying Hnf4tm1Gonz with transgenic mice expressing cre recombinase via the EIIa promoter. Expression of cre resulted in the excision of the floxed neomycin cassette, leaving a floxed region containing exons 4 and 5. Hnf4tm1.2Gonz was simultaneously generated by the same strategy. (J:67396)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 51 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hnf4a Mutation:  13 strains or lines available
Original:  J:67396 Hayhurst GP, et al., Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 2001 Feb;21(4):1393-403
All:  30 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory