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Targeted Allele Detail
Symbol: Pth1rtm3Hmk
Name: parathyroid hormone 1 receptor; targeted mutation 3, Henry M Kronenberg
MGI ID: MGI:2183514
Synonyms: Pthrd/d
Gene: Pth1r  Location: Chr9:110722085-110747145 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:77683
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsThis hypomorphic allele was identified in conjunction with Pthrtm2Hmk. Southern blot analyses showed three copies of the targeting vector, containing a floxed exon 1, at the endogenous locus. Levels of transcript were determined to be reduced in homozygous mutant mice via in situ hybridization of the growth plate and Northern blot analysis of total renal RNA. (J:77683)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:  10 strains or lines available
Original:  J:77683 Kobayashi T, et al., PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun;129(12):2977-86
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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