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Targeted Allele Detail
Symbol: Gjb2tm1Ugds
Name: gap junction protein, beta 2; targeted mutation 1, Unite de Genetique des Deficits Sensoriels
MGI ID: MGI:2183509
Synonyms: Cx26fl, Cx26fl, Cx26loxP, Gjb2tm1Ptt
Gene: Gjb2  Location: Chr14:57098600-57104702 bp, - strand  Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
Germline Transmission:  Earliest citation of germline transmission: J:77823
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe coding region in exon 2 was flanked by a loxP site in intron 1 and a floxed neo cassette inserted into exon 2. Immunohistofluorescence analysis showed that the expression pattern of this floxed allele did not differ from that of wild-type. (J:77823)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb2 Mutation:  13 strains or lines available
Original:  J:77823 Cohen-Salmon M, et al., Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol. 2002 Jul 9;12(13):1106-11
All:  19 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory