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Targeted Allele Detail
Symbol: Tgfbr2tm1.1Karl
Name: transforming growth factor, beta receptor II; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:2183504
Synonyms: T-Beta-RII-
Gene: Tgfbr2  Location: Chr9:116087695-116175363 bp, - strand  Genetic Position: Chr9, 68.39 cM
Germline Transmission:  Earliest citation of germline transmission: J:77844
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed genomic fragment encompassing exon 4 and a neo cassette was deleted via cre-mediated recombination in ES cells. A single loxP site was left upstream of exon 5. (J:77844)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:  7 strains or lines available
Original:  J:77844 Leveen P, et al., Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002 Jul 15;100(2):560-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory