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Fancatm1Faw
Targeted Allele Detail
Nomenclature
Symbol: Fancatm1Faw
Name: Fanconi anemia, complementation group A; targeted mutation 1, Fre Arwert
MGI ID: MGI:2183470
Synonyms: Fanca-
Gene: Fanca  Location: Chr8:123268300-123318576 bp, - strand  Genetic Position: Chr8, 72.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63742
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 7 were deleted by the insertion of a cassette comprised of a splice acceptor site, IRES-lacZ, and neo. Protein was undetected in homozygous mutant mice via Western blot analysis of splenic tissue. (J:63742)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fanca Mutation:  6 strains or lines available
References
Original:  J:63742 Cheng NC, et al., Mice with a targeted disruption of the fanconi anemia homolog fanca. Hum Mol Genet. 2000 Jul 22;9(12):1805-11
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory