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Kcnj12tm1Swz
Targeted Allele Detail
Nomenclature
Symbol: Kcnj12tm1Swz
Name: potassium inwardly-rectifying channel, subfamily J, member 12; targeted mutation 1, Thomas L Schwarz
MGI ID: MGI:2183432
Synonyms: Kir2.2-
Gene: Kcnj12  Location: Chr11:61022564-61071131 bp, + strand  Genetic Position: Chr11, 37.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78077
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire open reading frame of the endogenous gene was replaced with a neomycin selection cassette. (J:78077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj12 Mutation:  15 strains or lines available
References
Original:  J:78077 Zaritsky JJ, et al., Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Circ Res. 2000 Jul 21;87(2):160-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory