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Alppl2tm1Jlm
Targeted Allele Detail
Nomenclature
Symbol: Alppl2tm1Jlm
Name: alkaline phosphatase, placental-like 2; targeted mutation 1, Jose Luis Millan
MGI ID: MGI:2183412
Synonyms: EAP-, EAP.ko
Gene: Alppl2  Location: Chr1:87086694-87089928 bp, - strand  Genetic Position: Chr1, 44.05 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39015
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 5, exon 6, exon 7, and part of exon 8, were replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:39015)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alppl2 Mutation:  11 strains or lines available
References
Original:  J:39015 Narisawa S, et al., Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997 Mar;208(3):432-46
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory