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Olig2tm1(cre/Esr1*)Htak
Targeted Allele Detail
Summary
Symbol: Olig2tm1(cre/Esr1*)Htak
Name: oligodendrocyte transcription factor 2; targeted mutation 1, Hirohide Takebayashi
MGI ID: MGI:2183410
Synonyms: Olig2-, Olig2-CreER, Olig2KICreER, Olig2tm1(cre/Esr1)Htak, Olig2tm1(cre/Esr1)Yin
Gene: Olig2  Location: Chr16:91022345-91025565 bp, + strand  Genetic Position: Chr16, 52.6 cM
Alliance: Olig2tm1(cre/Esr1*)Htak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77821
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe portion of exon 2 encoding the basic helix-loop-helix domain was replaced with a cassette containing neo and tamoxifen-inducible cre genes. The expression of the inducible cre gene was driven by the endogenous promoter. (J:77821)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Olig2 (mouse)
Summary of all recombinase alleles driven by Olig2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olig2 Mutation:  36 strains or lines available
References
Original:  J:77821 Takebayashi H, et al., The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol. 2002 Jul 9;12(13):1157-63
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory