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Vdrtm1Gcm
Targeted Allele Detail
Summary
Symbol: Vdrtm1Gcm
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Geert Carmeliet
MGI ID: MGI:2183407
Synonyms: Leuvenlox, VDRlox
Gene: Vdr  Location: Chr15:97752308-97806177 bp, - strand  Genetic Position: Chr15, 53.85 cM
Alliance: Vdrtm1Gcm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo-cassette was inserted upstream of exon 2 and a third loxP site was introduced downstream of exon 2 via homologous recombination. Transient expression of cre recombinase in correctly targeted cells facilitated the removal of the neo cassette and was confirmed by Southern blot analysis. (J:72578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:  35 strains or lines available
References
Original:  J:72578 Van Cromphaut SJ, et al., Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13324-9
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory