Nectin2^tm1Smu
Targeted Allele Detail

Summary

• Symbol: Nectin2^tm1Smu
• Name: nectin cell adhesion molecule 2; targeted mutation 1, Steffen Mueller
• MGI ID: MGI:2183406
• Synonyms: nectin-2 (-), nectin-2^LacZ
• Gene: Nectin2 Location: Chr7:19450569-19483498 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Nectin2^tm1Smu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77804
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 2 and 3 were deleted by the insertion of a cassette containing lacZ and neo genes. The absence of encoded protein in homozygous mutant mice was determined via Western blot analysis of testicular lysates and immunofluorescent microscopy of testicular sections. (J:77804, J:85634)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nectin2 Mutation: 79 strains or lines available

References

• Original: J:77804 Ozaki-Kuroda K, et al., Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr Biol. 2002 Jul 9;12(13):1145-50
• All: 13 reference(s)