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Itga2tm1Ztr
Targeted Allele Detail
Nomenclature
Symbol: Itga2tm1Ztr
Name: integrin alpha 2; targeted mutation 1, Mary M Zutter
MGI ID: MGI:2183401
Synonyms: alpha2-
Gene: Itga2  Location: Chr13:114835916-114932041 bp, - strand  Genetic Position: Chr13, 64.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77798
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was flanked by an upstream floxed neo cassette and a loxP site inserted into intron 1. Transient transfection of ES cells with cre recombinase expression plasmids resulted in the excision of the neo cassette and exon 1. Flow cytometric analysis of platelets obtained from homozygous mutant mice showed an absence of surface expression. Western blot analysis of protein lysates from platelets and mammary glands confirmed the lack of protien. Neither full-length nor truncated transcript was detected by RT-PCR analysis of mammary gland lysates. (J:77798)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga2 Mutation:  42 strains or lines available
References
Original:  J:77798 Chen J, et al., The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis. Am J Pathol. 2002 Jul;161(1):337-44
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory