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Rbp3tm1Gil
Targeted Allele Detail
Nomenclature
Symbol: Rbp3tm1Gil
Name: retinol binding protein 3, interstitial; targeted mutation 1, Gregory I Liou
MGI ID: MGI:2183368
Synonyms: IRBP-
Gene: Rbp3  Location: Chr14:33954003-33964216 bp, + strand  Genetic Position: Chr14, 20.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77624
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 4.4kb of sequence was replaced by a PGK-neo selection cassette. The deleted region contained the promoter and all but 24 base pairs of exon 1. While transcript was undetected by RT-PCR analysis in homozygous mutant mice, Northern blot analysis of total retinal RNA showed the presence of a truncated transcript containing the PGK-neo transgene and the untargeted exons. Immunocytochemistry showed the absence of protein in homozygous mutant mice. Western blot analysis confirmed the staining results as well as verified the lack of protein produced from the truncated transcript. (J:77624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbp3 Mutation:  59 strains or lines available
References
Original:  J:77624 Liou GI, et al., Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. J Neurosci. 1998 Jun 15;18(12):4511-20
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory